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How Does “Nano” CBD Improve Topical Creams?

When it comes to cannabidiol, mammoth benefits can come in miniature packages, specifically, nano-sized liposomes in a topical cream. Whether you need support for muscles aches or joint pain, look help from nano CBD and a few of its synergistic friends.*

What Does Nano Mean?

Nano is short for “nanometer” and is a unit of measurement. Let’s start with a millimeter (0.039 inches) and move to a micrometer (micron) which is 1,000 times smaller. A nanometer is 1,000 times smaller than a micron and is the scale at which atoms and molecules are measured. To give you an idea of the nano range, a human hair is roughly 50 to 100 thousand nanometers wide. A red blood cell checks in at about 7,000 nanometers and a strand of DNA measures 2.5 nanometers in diameter. Like a butterfly versus an eagle, a nano particle can slip into some pretty narrow spaces. This feature makes it quite useful for skin penetration and bioavailability.

 

Nano Technology in Medicine

Nano liposomal preparation is designed to dramatically improve the absorption rate of compounds that would otherwise be difficult for the human body to absorb. In the case of topical CBD products (lotions, creams, balms and rubs), without nano amplification, the CBD particles are simply too large to effectively penetrate beneath the skin layers to reach the muscles and joints. Nano liposomal preparation addresses this problem and is an effective way to help the CBD penetrate deep beneath the skin layers to reach the muscles and joints.

Anatomy of a nano CBD liposome

Put simply, liposomes are microscopic-sized hollow spheres with one lipophilic (fat loving) and one hydrophilic (water loving) layer that encapsulate a targeted molecule or compound, in this case, CBD. Since the CBD molecule is a lipid (fat), when creating a liposome for it, the interior layer surrounding the CBD is lipophilic and the hydrophilic layer faces outward where it can be suspended in a water-based medium such as your blood plasma.

As you know, oil and water don’t stay mixed for long. After blending, the water sinks and the oil rises. Liposomes allow the fat-soluble cannabidiol to remain in an aqueous environment without separating from it. In other words, liposomes fix the problem of oil/water estrangement. They also solve the issue with CBD molecules clumping together. I’ll explain how important clumping is in a moment. First, where does the “nano” come into play?

 

Reasons for CBD nano liposomes

When applied topically, the anti-inflammatory properties of CBD offer great support for achy muscles and joints. Although ingesting CBD can do wonders for a hurting body, sometimes you need a little extra relief targeted to specific muscles and joints. Ordinary topical CBD products certainly can help, but to get the most out of CBD, the smaller the cannabidiol particles, the better. Super tiny units of CBD penetrate deeper into the skin while enhancing bioavailability.

Penetrability: Regular CBD molecules tend to clump to about 3 microns or 3,000 nanometers in size. However, the liposomal CBD in our KindUrth Muscle Relief Cream is encapsulated in submicron-sized bubbles of 80 to 150 nanometers. Why does that matter?

The cells in the top layer of skin, the stratum corneum or epidermis, are about 5,000 nanometers in size, which is advantageous for keeping toxins and infectious agents out. However, at 3,000 nanos, a CBD molecule can squeeze past the very top layer and enter the epidermis. That’s a good thing, but in the next layer, the dermis, cells are five times smaller – about 1,000 nanos – which means chunky CBD molecules will have a hard time working into the layer where the action starts taking place.

However, nano CBD can sink between the dermis cells and release its bounty where it matters most. Once in the dermis layer, the liposomes dissolve to release the CBD molecule. Deeper absorption means it can reach the bloodstream and begin interacting with your ECS for powerful relief of sore muscles and burning, achy joints.

Bioavailability of nano CBD: Researchers have long known that liposomal compounds of synthetic or phytochemical (plant-derived) molecules deliver therapies that can avoid most of the gastrointestinal tract. As a topical application, muscle relief cream avoids digestion and first-pass liver metabolism, meaning more of the active molecules remain in tissue or the bloodstream for better and longer lasting effects. With deeper penetration and greater bioavailability, you can get the same or better pain support with less CBD.

As efficient as it is, we didn’t stop with our lonely nano-encapsulated CBD. Rather, we chose to surround the CBD liposomes with a whole crew of dedicated firefighting companions skilled at dousing inflamed tissues.

Synergy of anti-inflammatory friends

While nano CBD works well on its own, we find a full complement of anti-inflammatory compounds lending a hand elevates the possibilities. Our carefully-selected Muscle Relief Cream formula includes the following enhancers: 

Arnica: Arnica montana, a European flowering plant in the same family as sunflowers, brings an exciting array of potential benefits. Its flavonoids and phenolic compounds are known for their antioxidant activity, but arnica is better known for its anti-inflammatory properties and ease of skin penetration.

Lavender: As a vaunted essential oil in aromatherapy, lavender also has been shown to possess a variety of therapeutic potential when used topically or orally. In preclinical studies lavender displayed measurable ability to tamp down inflammation and pain.

Rosemary: Recent studies (about 120 per year since 2010) of the common spice rosemary show it to have analgesic, anxiolytic and anti-inflammatory effects, among many others. Of course, traditional healers have known this all along, but heightened interest in rosemary’s pharmacokinetic mechanisms has made the plant the subject of extensive use in the field of alternative health. Also, rosemary contains high levels of vitamin C which improves absorption of the next ingredient on the roster.

Vitamin E: Vitamin E, long used in lotions, cosmetics and moisturizers, naturally penetrates and nourishes the skin. When combined with vitamin C, it penetrates tissue better and is thought to dissipate less quickly when exposed to ultraviolet light such as that from the sun. Studies also suggest that vitamin E works as an excellent liposomal encapsulator of other compounds, creating exceptionally uniform and stable bubbles that offer more of a controlled release of the interior molecules.

Menthol: While not biologically active in the same way as CBD, vitamin E, rosemary, lavender and arnica, menthol functions as a counterirritant instead. Like its cousin counterirritants capsaicin and camphor, menthol creates a sensation on the skin (cooling) which serves in two ways against the sensation of pain. First, it triggers your nerves sensitive to thermal changes which can distract you from feeling the fullness of the underlying discomfort. Second, and more importantly, by irritating the area neurologically, menthol may actively inhibit the pain-sensing nerves (nociceptors), blocking their attempts to reach your brain to file an urgent report. This interference can act in conjunction with the other ingredients in our cream to keep you comfortable when muscles and joints are sore.

Our premium nano CBD absorbs better along with its loyal team of collaborative botanicals and vitamins. Here’s what our customer William L. has to say about it:

“I’m not much for these kinds of things. People tell you they work, but they don’t. However, i tried it…..and….amazing! It worked! Haven’t had any troubles since i started using it. Fantastic.”

You’ll find 300 mgs of nano CBD in 50 ml of enhanced cream per bottle… should be plenty for up to 250 applications. Massage a small amount into joints, muscles, bumps and thumps for rapid, long-lasting relief. Get your CBD Muscle Relief Cream today!

Sources:

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Gustafson, Craig. Christopher W. Shade, PhD: The Vast Potential of Liposomal Delivery of Nutraceuticals. Interview. Alternative Therapies in Health and Medicine (2016).

Nimmathota Madhavi et al. Colloidal Dispersions (Liposomes and Ethosomes) for Skin Drug Delivery and their Role on Rheumatoid Arthritis. Asian Journal of Pharmaceutic (2016).

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Khadigeh Mirzaiinajmabadi et al. An Update on the Effect of Massage and Inhalation Aromatherapy with Lavender on Labor Pain Relief: A Systematic Review and Meta-analysis. Journal of Obstetrics, Gynecology and Cancer Research. (2018).

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Mahboobeh Ghasemzadeh Rahbardar et al. Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. Elsiever (2017).

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